The Hoops striker was struck down by a hamstring injury and missed the 5-1 demolition of the Ibrox outfit last month.
Dembele led the line in his place and thumped in the perfect hat-trick against the Ibrox men with Scott Sinclair and Stuart Armstrong adding the others.
Rodgers has kept faith with Dembele ever since his excellent display against Mark Warburton’s team.
Griffiths, 26, hasn’t started for the Hoops since the 4-1 win over Aberdeen on August 27 and has come off the subs’ bench for his last five appearances.
But the prolific frontman is convinced he and Dembele could wreak havoc at the national stadium.
He said: “There’s been a lot of talk about the manager fitting us both into the team. That’s up to him, whether he can or can’t. If not, I will sit on the bench and wait for my chance.
“Could he play with both of us against Rangers? That’s a question for the manager.
“Would I like to see it? Of course, I would as it would mean I am back in the team.
“Both of us up top is something the fans would want to see. Rangers wouldn’t be expecting it, they would be surprised by it.
“But the two people who would find it most enjoyable would be myself and Moussa because we could go and run riot.”